CRISPR, which stands for clustered regularly interspaced short palindromic repeats, is a DNA editing technology that has the potential to improve crop production and quality, as well as benefit livestock and aquaculture. The global CRISPR market is expected to experience a significant growth rate of 25.3% during the forecast period (2018-2025), with revenues predicted to reach $596.0 million by 2025, up from $126.0 million in 2018. The growth of the CRISPR market in agriculture is being driven by increased research activities, which are being supported by public and private funding. As the adoption of this technology is still in its early stages, research programs are playing a crucial role in promoting the adoption of genetically modified products.
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Market Trends
CRISPR is a revolutionary gene editing technology that is transforming the agriculture industry. CRISPR is being used to create crops that are more resistant to pests, diseases, and environmental stressors. Hence, there are several growing trends in this technology. Some of them include-
Increased Demand for Genetically Modified (GM) Crops
The use of CRISPR in agriculture has led to the development of GM crops that can withstand harsh environments, pests, and diseases. Some GM crops have been developed to be more nutritious than their non-GM counterparts. For instance, GM rice has been developed to contain higher levels of vitamin A, which reduces vitamin A deficiency in developing countries. These are also known as Golden rice. This has led to increased demand for these crops as they are more productive and resilient.
Focus on Sustainable Agriculture
With the global population growing, there is a need for sustainable agriculture that can produce enough food for everyone without harming the environment. CRISPR has enabled the development of crops that require fewer pesticides and fertilizers, reducing the environmental impact of agriculture. GM crops can contribute to more sustainable agriculture practices by reducing the need for tillage, conserving water, and reducing greenhouse gas emissions.
Growing Demand for Organic Produce
While there is an increasing demand for genetically modified crops, there is also a growing demand for organic produce. CRISPR is being used to develop organic crops that are more resilient and have a longer shelf life, which is increasing their popularity among consumers.
Private and Public Organizations’ Initiatives
The potential of CRISPR in agriculture has led to increased investment in R&D. Companies and governments are investing heavily in developing new CRISPR-based products that can improve crop yields, reduce waste, and increase sustainability. According to the Federation of American Scientists, around $1.1 billion of funding was recorded from the National Institute of Health (NIH) for CRISPR technology in 2018. It increased from just $5 million in 2011 to $85 million in 2014.
Additionally, in January 2022, China announced trial rules for gene-edited plant approval, clearing the possibility for faster crop advancements. The new recommendations, issued by the Ministry of Agriculture and Rural Affairs, are part of a slew of initiatives aimed at revitalizing the country's seed business. The proposed guidelines state that after gene-edited plants have passed pilot testing, a production certificate can be requested, bypassing the long field trials necessary for genetically modified plant licensing.
Recent Developments
The key companies in the CRISPR in the agriculture market include Pioneer Hi-Bred International, Inc.; Dupont Nutrition Biosciences APS; Caribou Biosciences, Inc.; DSM IP Assets B.V.; Snipr Technologies Ltd.; and others. These companies are offering various innovative solutions, following mergers, and making investments to meet the rising demand of the market. Some of the market developments include-
• In January 2023, Aldevron, a biotech company that develops and produces plasmid DNA, RNA, and proteins, introduced Eureca-V Nuclease, a wild-type MAD7 CRISPR Type-V nuclease licensed from Inscripta at Research Grade, with GMP to follow. The introduction of Aldevron's Eureca-V Nuclease at Advanced Therapies Week enhances the toolset of accessible CRISPR nucleases for therapeutic, diagnostic, and agricultural applications. A pass-through license for research usage is included with the purchase of Eureca-V Nuclease, allowing clients to completely examine the product without committing to a long-term licensing deal.
• In July 2022, NAPIGEN, a firm developing a patented technology to modify mitochondrial and chloroplast genomes, closed a seed fundraising round of $7.85 million. NAPIGEN will utilize the funds to develop hybrid seed production in wheat and rice using its mitochondrial gene editing technique. Additionally, NAPIGEN will leverage its technology to produce mitochondrial expression systems useful for plant mitochondria.
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